Gene name:
LYVE1 (UNQ230/PRO263;CRSBP1;HAR;XLKD1) ;
Protein name:
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) ;
Alternative:
Extracellular link domain-containing protein 1 ;Cell surface retention sequence-binding protein 1 (CRSBP-1) ;Hyaluronic acid receptor ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.
Function:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
Protein Attributes:
50:
MARCFSLVLL | LTSIWTTRLL | VQGSLRAEEL | SIQVSCRIMG | ITLVSKKANQ |
100:
QLNFTEAKEA | CRLLGLSLAG | KDQVETALKA | SFETCSYGWV | GDGFVVISRI |
150:
SPNPKCGKNG | VGVLIWKVPV | SRQFAAYCYN | SSDTWTNSCI | PEIITTKDPI |
200:
FNTQTATQTT | EFIVSDSTYS | VASPYSTIPA | PTTTPPAPAS | TSIPRRKKLI |
250:
CVTEVFMETS | TMSTETEPFV | ENKAAFKNEA | AGFGGVPTAL | LVLALLFFGA |
300:
AAGLGFCYVK | RYVKAFPFTN | KNQQKEMIET | KVVKEEKAND | SNPNEESKKT |
322:
DKNPEESKSP | SKTTVRCLEA | EV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
ELISA Kit for Human LYVE-1
ELISA Kit for Human LYVE-1
ELISA Kit for Human LYVE-1
CLIA Kit for Human LYVE-1
CLIA Kit for Human LYVE-1
CLIA Kit for Human LYVE-1
Polyclonal Antibody for Human LYVE-1
Polyclonal Antibody for Human LYVE-1
Polyclonal Antibody for Human LYVE-1
Monoclonal Antibody for Human LYVE-1
Monoclonal Antibody for Human LYVE-1
Monoclonal Antibody for Human LYVE-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
2.
"HAR: a novel homolog of CD44 and putative hyaluronic acid receptor encoded by a gene on human chromosome 11p15."
Winkelmann J.C.
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Basu S.
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Ozdemir E.
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Blough R.I.
Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
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more...
Genome Res.13:2265-2270(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-116
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53
tissue :
Plasma .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53
tissue :
Liver .